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1.

APOE told me put my fat in the bag and nobody gets hurt.

Kim, Garam; Gitler, Aaron D.

Cell ; 185(13): 2201-2203, 2022 06 23.

Artículo en Inglés | MEDLINE | ID: mdl-35750028

2.

A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation.

Dorone, Yanniv; Boeynaems, Steven; Flores, Eduardo; Jin, Benjamin; Hateley, Shannon; Bossi, Flavia; Lazarus, Elena; Pennington, Janice G; Michiels, Emiel; De Decker, Mathias; Vints, Katlijn; Baatsen, Pieter; Bassel, George W; Otegui, Marisa S; Holehouse, Alex S; Exposito-Alonso, Moises; Sukenik, Shahar; Gitler, Aaron D; Rhee, Seung Y.

Cell ; 184(16): 4284-4298.e27, 2021 08 05.

Artículo en Inglés | MEDLINE | ID: mdl-34233164

3.

p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR).

Maor-Nof, Maya; Shipony, Zohar; Lopez-Gonzalez, Rodrigo; Nakayama, Lisa; Zhang, Yong-Jie; Couthouis, Julien; Blum, Jacob A; Castruita, Patricia A; Linares, Gabriel R; Ruan, Kai; Ramaswami, Gokul; Simon, David J; Nof, Aviv; Santana, Manuel; Han, Kyuho; Sinnott-Armstrong, Nasa; Bassik, Michael C; Geschwind, Daniel H; Tessier-Lavigne, Marc; Attardi, Laura D; Lloyd, Thomas E; Ichida, Justin K; Gao, Fen-Biao; Greenleaf, William J; Yokoyama, Jennifer S; Petrucelli, Leonard; Gitler, Aaron D.

Cell ; 184(3): 689-708.e20, 2021 02 04.

Artículo en Inglés | MEDLINE | ID: mdl-33482083

4.

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport.

Zhang, Ke; Daigle, J Gavin; Cunningham, Kathleen M; Coyne, Alyssa N; Ruan, Kai; Grima, Jonathan C; Bowen, Kelly E; Wadhwa, Harsh; Yang, Peiguo; Rigo, Frank; Taylor, J Paul; Gitler, Aaron D; Rothstein, Jeffrey D; Lloyd, Thomas E.

Cell ; 173(4): 958-971.e17, 2018 05 03.

Artículo en Inglés | MEDLINE | ID: mdl-29628143

5.

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains.

Guo, Lin; Kim, Hong Joo; Wang, Hejia; Monaghan, John; Freyermuth, Fernande; Sung, Julie C; O'Donovan, Kevin; Fare, Charlotte M; Diaz, Zamia; Singh, Nikita; Zhang, Zi Chao; Coughlin, Maura; Sweeny, Elizabeth A; DeSantis, Morgan E; Jackrel, Meredith E; Rodell, Christopher B; Burdick, Jason A; King, Oliver D; Gitler, Aaron D; Lagier-Tourenne, Clotilde; Pandey, Udai Bhan; Chook, Yuh Min; Taylor, J Paul; Shorter, James.

Cell ; 173(3): 677-692.e20, 2018 04 19.

Artículo en Inglés | MEDLINE | ID: mdl-29677512

6.

Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates.

Boeynaems, Steven; Dorone, Yanniv; Zhuang, Yanrong; Shabardina, Victoria; Huang, Guozhong; Marian, Anca; Kim, Garam; Sanyal, Anushka; Sen, Nesli-Ece; Griffith, Daniel; Docampo, Roberto; Lasker, Keren; Ruiz-Trillo, Iñaki; Auburger, Georg; Holehouse, Alex S; Kabashi, Edor; Lin, Yi; Gitler, Aaron D.

Mol Cell ; 83(12): 2020-2034.e6, 2023 Jun 15.

Artículo en Inglés | MEDLINE | ID: mdl-37295429

7.

Rnq1! You are still dangerous, but you can be my wingman anytime.

Guo, Caiwei; Gitler, Aaron D.

Mol Cell ; 82(22): 4194-4196, 2022 11 17.

Artículo en Inglés | MEDLINE | ID: mdl-36400005

8.

A template for new drugs against Alzheimer's disease.

Aguzzi, Adriano; Gitler, Aaron D.

Cell ; 154(6): 1182-4, 2013 Sep 12.

Artículo en Inglés | MEDLINE | ID: mdl-24034239

9.

TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A.

Ma, X Rosa; Prudencio, Mercedes; Koike, Yuka; Vatsavayai, Sarat C; Kim, Garam; Harbinski, Fred; Briner, Adam; Rodriguez, Caitlin M; Guo, Caiwei; Akiyama, Tetsuya; Schmidt, H Broder; Cummings, Beryl B; Wyatt, David W; Kurylo, Katherine; Miller, Georgiana; Mekhoubad, Shila; Sallee, Nathan; Mekonnen, Gemechu; Ganser, Laura; Rubien, Jack D; Jansen-West, Karen; Cook, Casey N; Pickles, Sarah; Oskarsson, Björn; Graff-Radford, Neill R; Boeve, Bradley F; Knopman, David S; Petersen, Ronald C; Dickson, Dennis W; Shorter, James; Myong, Sua; Green, Eric M; Seeley, William W; Petrucelli, Leonard; Gitler, Aaron D.

Nature ; 603(7899): 124-130, 2022 03.

Artículo en Inglés | MEDLINE | ID: mdl-35197626

10.

Just Took a DNA Test, Turns Out 100% Not That Phase.

Gitler, Aaron D; Shorter, James; Ha, Taekjip; Myong, Sua.

Mol Cell ; 78(2): 193-194, 2020 04 16.

Artículo en Inglés | MEDLINE | ID: mdl-32302539

11.

Neurotoxic reactive astrocytes induce cell death via saturated lipids.

Guttenplan, Kevin A; Weigel, Maya K; Prakash, Priya; Wijewardhane, Prageeth R; Hasel, Philip; Rufen-Blanchette, Uriel; Münch, Alexandra E; Blum, Jacob A; Fine, Jonathan; Neal, Mikaela C; Bruce, Kimberley D; Gitler, Aaron D; Chopra, Gaurav; Liddelow, Shane A; Barres, Ben A.

Nature ; 599(7883): 102-107, 2021 11.

Artículo en Inglés | MEDLINE | ID: mdl-34616039

12.

You come at the misfolded proteins, you best not miss.

Boeynaems, Steven; Gitler, Aaron D.

Trends Biochem Sci ; 47(1): 1-2, 2022 01.

Artículo en Inglés | MEDLINE | ID: mdl-34654581

13.

Pour Some Sugar on TDP(-43).

Boeynaems, Steven; Gitler, Aaron D.

Mol Cell ; 71(5): 649-651, 2018 09 06.

Artículo en Inglés | MEDLINE | ID: mdl-30193092

14.

Singling out motor neurons in the age of single-cell transcriptomics.

Blum, Jacob A; Gitler, Aaron D.

Trends Genet ; 38(9): 904-919, 2022 09.

Artículo en Inglés | MEDLINE | ID: mdl-35487823

15.

Radiogenomics of C9orf72 Expansion Carriers Reveals Global Transposable Element Derepression and Enables Prediction of Thalamic Atrophy and Clinical Impairment.

Bonham, Luke W; Geier, Ethan G; Sirkis, Daniel W; Leong, Josiah K; Ramos, Eliana Marisa; Wang, Qing; Karydas, Anna; Lee, Suzee E; Sturm, Virginia E; Sawyer, Russell P; Friedberg, Adit; Ichida, Justin K; Gitler, Aaron D; Sugrue, Leo; Cordingley, Michael; Bee, Walter; Weber, Eckard; Kramer, Joel H; Rankin, Katherine P; Rosen, Howard J; Boxer, Adam L; Seeley, William W; Ravits, John; Miller, Bruce L; Yokoyama, Jennifer S.

J Neurosci ; 43(2): 333-345, 2023 01 11.

Artículo en Inglés | MEDLINE | ID: mdl-36446586

16.

Evolution of a Human-Specific Tandem Repeat Associated with ALS.

Course, Meredith M; Gudsnuk, Kathryn; Smukowski, Samuel N; Winston, Kosuke; Desai, Nitin; Ross, Jay P; Sulovari, Arvis; Bourassa, Cynthia V; Spiegelman, Dan; Couthouis, Julien; Yu, Chang-En; Tsuang, Debby W; Jayadev, Suman; Kay, Mark A; Gitler, Aaron D; Dupre, Nicolas; Eichler, Evan E; Dion, Patrick A; Rouleau, Guy A; Valdmanis, Paul N.

Am J Hum Genet ; 107(3): 445-460, 2020 09 03.

Artículo en Inglés | MEDLINE | ID: mdl-32750315

17.

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice.

Becker, Lindsay A; Huang, Brenda; Bieri, Gregor; Ma, Rosanna; Knowles, David A; Jafar-Nejad, Paymaan; Messing, James; Kim, Hong Joo; Soriano, Armand; Auburger, Georg; Pulst, Stefan M; Taylor, J Paul; Rigo, Frank; Gitler, Aaron D.

Nature ; 544(7650): 367-371, 2017 04 20.

Artículo en Inglés | MEDLINE | ID: mdl-28405022

18.

A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS.

Gelfman, Sahar; Dugger, Sarah; de Araujo Martins Moreno, Cristiane; Ren, Zhong; Wolock, Charles J; Shneider, Neil A; Phatnani, Hemali; Cirulli, Elizabeth T; Lasseigne, Brittany N; Harris, Tim; Maniatis, Tom; Rouleau, Guy A; Brown, Robert H; Gitler, Aaron D; Myers, Richard M; Petrovski, Slavé; Allen, Andrew; Goldstein, David B; Harms, Matthew B.

Genome Res ; 29(5): 809-818, 2019 05.

Artículo en Inglés | MEDLINE | ID: mdl-30940688

19.

Defects in trafficking bridge Parkinson's disease pathology and genetics.

Abeliovich, Asa; Gitler, Aaron D.

Nature ; 539(7628): 207-216, 2016 11 10.

Artículo en Inglés | MEDLINE | ID: mdl-27830778

20.

A cellular system that degrades misfolded proteins and protects against neurodegeneration.

Guo, Lili; Giasson, Benoit I; Glavis-Bloom, Alex; Brewer, Michael D; Shorter, James; Gitler, Aaron D; Yang, Xiaolu.

Mol Cell ; 55(1): 15-30, 2014 Jul 03.

Artículo en Inglés | MEDLINE | ID: mdl-24882209

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